Efforts Towards the Development of New Antitubercular Agents: Potential for Thiolactomycin Based Compounds
نویسندگان
چکیده
منابع مشابه
Efforts towards the development of new antitubercular agents: potential for thiolactomycin based compounds.
Development of new chemotherapeutic drugs is the need of the hour to improve tuberculosis control, particularly in the developing world. In the last fourty years no new compound has been brought to the market for the treatment of tuberculosis. However, in recent years there is an enhanced activity in the research and development of new drugs for TB. Some compounds are presently in clinical deve...
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Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N-acetyltransferase (NAT), an enzyme essential for mycobacterial survival inside macrophages. The NAT inhibition involves a prodrug-like mechanism in which acti...
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Vrious antitubercular agents are used the control and treatment of tuberculosis (TB). Currently, various works is going on in the research and development of new antiTB drugs for less side effects, more potent, short period of therapy and more importantly acive against multi drug resistant strains of Mycobacterium. In this continuation we study here thiolactomycin (TLM) and it analogues as anti...
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متن کاملCryptolepine and development of new antimalarial agents
Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...
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ژورنال
عنوان ژورنال: Journal of Pharmacy & Pharmaceutical Sciences
سال: 2008
ISSN: 1482-1826,1482-1826
DOI: 10.18433/j36k5k